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ATI Vaccines

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Sample questions from ATI Vaccines

This material has 90 questions with answers and rationales. Here are the first 5.

  1. 1.At a community health clinic, a 2-month-old infant is due for routine immunizations. The infant is afebrile, feeding well, and has no history of vaccine reactions. Which vaccine should the nurse expect to administer by the intramuscular route?

    • A.Rotavirus vaccine
    • B.Varicella vaccine
    • C.Inactivated poliovirus vaccine (IPV)
    • D.Measles, mumps, and rubella vaccine (MMR)

    Rationale: IPV is given by the intramuscular or subcutaneous route and is part of the routine infant series. Rotavirus is oral, while MMR and varicella are generally first given at 12 to 15 months. The age-based vaccine schedule is an important check before administration.

  2. 2.A 6-month-old is seen at a primary care clinic for scheduled vaccines. The parent reports the infant had a mild cold last week but is now well; the infant is afebrile and has no vaccine contraindications. Refer to the client's chart. Which actions should the nurse take? Select all that apply.

    • A.Administer all injectable vaccines in the same exact site.
    • B.Review the infant's immunization record before selecting doses.
    • C.Provide the parent with the current Vaccine Information Statements (VISs).
    • D.Give the rotavirus vaccine orally if the infant is within the permitted age range.
    • E.Document the vaccine, lot number, route, site, and date after administration.
    • F.Defer all vaccines because of the recent mild cold.

    Rationale: The chart confirms the infant is well and due for age-appropriate vaccines, so the record and current VISs should be reviewed and administration documented. A mild, resolved illness is not generally a reason to defer vaccination, and rotavirus vaccine is oral. Injectable vaccines may be given at separate sites, not all in the same exact site.

  3. 3.During discharge planning on a pediatric unit, a 4-year-old is due for a second dose of varicella vaccine. The child has no fever or immunosuppression and takes no immunosuppressive medication. Which action is appropriate?

    • A.Withhold the vaccine because all live vaccines are contraindicated in children.
    • B.Administer the live attenuated vaccine as scheduled.
    • C.Administer varicella vaccine only after confirming a positive antibody titer.
    • D.Give varicella vaccine by the oral route.

    Rationale: A healthy 4-year-old can receive the recommended second dose of live attenuated varicella vaccine. Live vaccines are contraindicated in some circumstances, such as severe immunosuppression, but not in all children. Varicella vaccine is not oral, and routine serologic confirmation is not required before vaccination.

  4. 4.At change of shift in an outpatient clinic, a registered nurse delegates vaccine administration to a licensed practical nurse (LPN). Which client is most appropriate for the LPN to vaccinate under the clinic's policy?

    • A.A stable adult receiving a previously tolerated influenza vaccine with no allergy history
    • B.A child with a history of anaphylaxis after a prior vaccine
    • C.An infant with a complex history of immunodeficiency and uncertain vaccine eligibility
    • D.A client who is acutely short of breath after a vaccine given minutes earlier

    Answer and rationale are in the full material.

  5. 5.In an employee health clinic, a 29-year-old nurse is found to have no documented hepatitis B vaccination or immunity. The nurse is not pregnant and has no known contraindications. Which actions are appropriate? Select all that apply.

    • A.Tell the employee that one dose provides lifelong protection for everyone.
    • B.Advise the employee to stop using standard precautions after vaccination.
    • C.Explain that a hepatitis B vaccine series is recommended for health care personnel at risk for blood exposure.
    • D.Document each dose and schedule follow-up doses.
    • E.Start an approved hepatitis B vaccine series according to the product schedule.
    • F.Arrange postvaccination anti-HBs testing when indicated by occupational risk and policy.

    Answer and rationale are in the full material.

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Released October 30, 2026 · Independent original practice and study material.